NR or nicotinamide riboside supplements are gaining popularity as another longevity product acting similarly to NMN (nicotinamide mononucleotide). NR supplements are suggested to replenish NAD+ levels in the body and support healthy aging.
However, the question remains — how to find the best NR supplements on the market, abundant with various formulations? For this reason, we conducted market research and selected 6 NR products that, in our opinion, stand out in quality.
Best NR supplement: shortlist
- Overall best price for NR supplement: partiQlar
- Best NR and TMG supplement: ProHealth
- Best NR supplement with improved bioavailability: GenuinePurityTM
- Best nicotinamide riboside for liver: Elysium
- Best overall NR supplement for longevity: Tru Niagen®
- Top-quality UK brand of NR: VitalityPRO
Your well-being is our top priority. Our in-house Research team and expert fact-checkers diligently review every content piece, ensuring you receive accurate, safe, and up-to-date health information to support your health decisions. Get an inside look at our thorough testing framework.
Why do we think partiQlar is the best NR supplement?
We picked partiQlar as the best NR supplement because of its positive customer reviews, timely delivery, and comparatively low price.
Other factors that determined our decision were the brand's transparent approach, high-quality supplement formulation, and third-party testing results.
How did we evaluate the best NR supplements?
Our team has spent over 120 hours reading scientific research material on cellular aging, NR and other NAD+ precursors, and NAD+ metabolism in general.
Best NR supplements in 2025: overview
Based on our analysis, partiQlar is the best NR supplement on the list. We selected this product based on thorough research of the brand claims, supplement formulation, and third-party testing results.
Read on to choose the best product that may suit your needs and accompany you in your longevity journey.
1. partiQlar — best price for NR supplement per serving size
partiQlar offers a reasonable price for serving size for its Pure NR supplement. Moreover, the provider offers significant discounts with multi-buy options for more prolonged consumption.
The raw ingredient in partiQlar is sourced from Effepharm, which is a reliable supplier of NMN and NR compounds. The provider claims nicotinamide riboside to be 99% pure.
The products are developed in cGMP-certified and FDA-compliant manufacturing facilities. partiQlar’s Pure NR is also NSF Certified for Sport®, vegan, and free from artificial colors, allergens, and GMOs.
The provider recommends taking one capsule a day to receive 500 mg NR. The supplement features nicotinamide riboside chloride and undergoes third-party testing to ensure the purity of the active compound aligns with the claims made on the label.
You can order your 2-month supply of partiQlar Pure NR at $54.99 ($0.92 per serving).
What users like about partiQlar
Although as a newly established company with a limited number of customer reviews compared to other brands, we have identified unbiased opinions of what users like about partiQlar NR:
- Timely delivery
- Helpful customer service
- Comparably lower price
What users don’t like about partiQlar
Some customers mentioned the following issues with partiQlar:
- Unexpected custom fees
- Slow shipment for international orders
- Technical issues with the website
Company review
Despite being a newly established company, partiQlar is rapidly distinguishing itself in the longevity supplement market by prioritizing transparency and customer satisfaction.
Specializing in high-quality supplements like Resveratrol, TMG, and others, partiQlar ensures each product meets stringent standards through rigorous third-party testing and adherence to FDA and NSF guidelines. Their commitment to sourcing from trusted suppliers and providing detailed product information underscores their dedication to quality.
Our verdict about partiQlar
For those looking for a high-quality NR supplement made in the EU, partiQlar may be the best choice. The brand has a strong commitment to sourcing high-purity ingredients from trusted suppliers like Effepharm and adhering to manufacturing standards, including FDA and NSF certifications.
According to the majority of positive customer reviews, you may also enjoy the brand’s aim to provide fast delivery and excellent customer service.
2. ProHealth — best NR and TMG supplement formula
ProHealth combines TMG (betaine) with NR — making it a promising supplement option for people seeking to support liver function and promote muscle formation and cellular reproduction.
ProHealth utilizes NIAGEN® nicotinamide riboside by CromaDex. The manufacturing is handled in the USA, cGMP-certified facilities. Another quality standard is the third-party testing displayed on the product page.
ProHealth NR supplements are available in 2 NR dosage amounts — 300 mg and 500 mg. TMG doses also differ in these two options — 150 mg and 250 mg, respectively.
The bottle of ProHealth nicotinamide riboside 500 mg is sold at $64.95 ($2.16 per serving). The 300 mg option is available for 30 days at $47.30 ($1.57 per serving).
What users like about ProHealth
Based on a number of customer reviews on the brand’s website and Amazon store, these are the positive aspects users like about ProHealth and its NR supplement:
- Energy improvement
- Trustworthy brand
- Integrated combination of TMG and NR
What users don’t like about ProHealth
While positive reviews are predominant, we have highlighted the issues that people mention about ProHealth that they don't like:
- Stomach discomfort
- Partially filled capsules
- Issues with customer service
Company review
Founded by Rich Carson out of a personal need to manage chronic illness, ProHealth has grown into a trusted name in the supplement industry over its 35-year journey. Beyond supplements, they provide cutting-edge research updates and personalized nutritional guidance.
ProHealth maintains its leadership in the wellness industry with an A+ BBB rating, underscoring its commitment to excellence in supplement production.
Our verdict about ProHealth
ProHealth’s combination of TMG and NR presents a convenient option for individuals interested in supplementing with these longevity molecules in a single capsule for potentially promoting longevity and increased energy.
Additionally, with a longstanding commitment to scientific rigor and decades of experience, ProHealth may be a reliable choice in the wellness industry.
3. GenuinePurity™ — best NR supplement with improved bioavailability
GenuinePurityTM goes beyond mere ingredient selection, prioritizing both safe doses and absorption in their NR supplement. Utilizing clinically tested nicotinamide riboside in optimal amounts, they enhance bioavailability through liposomes derived from sunflower lecithin.
According to the provider and the research it references, NR faces absorption challenges in stomach acids. By encapsulating it in liposomal capsules, the manufacturer aims to protect the compound, aiding its utilization in the bloodstream.
GenuinePurityTM provides 2 Certificates of Analysis (COA) — one confirming the supplement content matches label claims and the other verifying the absence of contaminants and heavy metals.
According to the third-party lab tests, this supplement from GenuinePurityTM contains 95.50% nicotinamide riboside. We like the brand’s transparency regarding scientific findings about NR, its effects on the body, as well as consumption recommendations.
Adults are recommended to take 2 daily capsules of GenuinePurityTM NR delivering 300 mg of the compound. Notably, the manufacturer offers a 97-day full-money-back guarantee, enabling you to test the supplement and return it if you don't experience the promised effects.
A one-time purchase of GenuinePurityTM NR is $69.95 ($2.33 per serving). If you are interested in investing in a long-term supplementation, choose the brand's 3 or 6-month supplies for substantial discounts.
What users like about GenuinePurity™
Based on Amazon reviews from GenuinePurityTM customers, here are the main positive aspects highlighted:
- Liposomal formula
- Manufacturing standards
- Potential health benefits
- Easy-to-swallow capsules
What users don’t like about GenuinePurity™
Although positive reviews are superior, there are customers reporting negative experiences or aspects of GenuinePurityTM NR:
- Higher price
- No detailed information on the label
- Insufficient company information on the web
Company review
GenuinePurity™ is a supplement created by Leading Edge Health, a reputable health-focused brand based in Canada that serves customers in over 130 countries.
Leading Edge Health focuses on enhancing overall well-being through natural ingredients and formulations. The company’s product line includes supplements for anti-aging, cognitive function, sexual health, and general wellness.
Our verdict about GenuinePurity™
Based on our review, customer feedback, and company reputation, GenuinePurityTM stands out as one of the leading brands in the NR market. The product itself is praised for being produced in facilities following high-quality standards and being formulated according to available scientific evidence.
The liposomal formula, which is proposed to improve the molecule's bioavailability, is another plus for people looking for quality NR supplements.
4. Elysium — best nicotinamide riboside formula for liver health
Elysium Basis is a formula of pterostilbene (PT) and nicotinamide riboside (NR-E). The combination has been tested in a clinical trial and shown well-tolerated during 6-month supplementation in people with non-alcoholic fatty liver disease. It was also associated with reduced inflammatory markers in the liver.
The manufacturer included nicotinamide riboside crystalline in the supplement as another NR form. NR-E in Basis was developed by the eminent scientists behind Elysium and is a patent-pending product.
Basis by Elysium is manufactured in cGMP-certified facilities and is certified NSF for sport. It is free from allergens and GMOs. It is also third-party tested for safety and purity.
The daily recommended dose of Basis is 2 capsules in the morning, delivering 250 mg of NR-E and 50 mg of PT.
One month's supply of Elysium Basis NR-E costs $60.00 ($2.00 per serving). The provider offers significant discounts with multi-buy options.
What users like about Elysium
Here are the highlighted aspects users like about Elysium NR and the brand:
- Ease-to-swallow capsules
- Well-designed packaging
- Brand transparency about scientific findings
What users don’t like about Elysium
Based on customer feedback, here are the main issues people have with Elysium:
- Damaged products during delivery
- Issues with managing subscriptions
- Concerns with customer service
Company review
Founded with a commitment to scientific findings and collaboration, Elysium utilizes insights from Nobel Prize-winning advisors and a network of over 25 world-renowned researchers. Led by co-founder Dr. Leonard Guarente, whose pioneering work on SIR2 and NAD+ laid the foundation for their flagship product Basis, Elysium continues to innovate in proactive health.
Our verdict About Elysium
For anyone searching for a reliable NR brand led by renowned scientists in the longevity field, Elysium may be an ideal candidate. Despite occasional issues with delivery and subscriptions reported by some customers, its commitment to transparency and clinical validation makes it a compelling choice for those prioritizing their well-being.
5. Tru Niagen® — best overall NR supplement on the market
Tru Niagen® is one of the best NR supplements on the market, produced as a flagship product incorporating clinically tested safe and effective NIAGEN® nicotinamide riboside.
ChromaDex, the manufacturer of the NR ingredient, conducted a clinical trial where NIAGEN® was observed to increase NAD+ levels by 50% after a short-term supplementation.
The brand is NSF-certified for sports (National Sanitation Foundation). This is a reputable third-party organization assessing the safety and purity of dietary supplements.
Tru Niagen® offers a versatile choice of servings per bottle of encapsulated NR.
Our pick of the best option for servings per bottle would be the bottle containing 90 capsules for 3 month's supply. With 1 capsule serving daily, you will receive 300 mg NR.
This option of Tru Niagen® NR supplement is sold at $119.95 ($1.33 per serving).
What users like about Tru Niagen®
We analyzed the customer feedback of Tru Niagen® across the brand’s official website, Amazon, and Trustpilot, and here are the key aspects that users appreciate about the product:
- Significant energy improvements
- Fast delivery
- Quality packaging
- Scientific backing
What users don’t like about Tru Niagen®
Here are the main aspects users report not liking about Tru Niagen® and its NR product:
- Allergic reactions
- Comparably higher priced
- Issues with returns
Company review
Tru Niagen®, developed by ChromaDex, stands out as a leader in the NAD+ supplement market, supported by robust scientific backing and endorsements from Nobel Prize-winning scientists.
ChromaDex's commitment to scientific evidence is evident in over 300 published studies and regulatory approvals. With an emphasis on transparency and quality, Tru Niagen® aims to enhance cellular health and vitality, making it a trusted choice for those prioritizing longevity and well-being.
Our verdict about Tru Niagen®
Tru Niagen® is considered a leader specializing in creating NR supplements based on rigorous scientific research. The brand’s numerous certificates underline its commitment to production safety, transparency, and purity standards.Based on the brand’s claims, clinical findings, and customer reviews, Tru Niagen® may be a great choice for individuals looking for enhanced energy levels and focus, and potential skin improvements.
6. VitalityPRO — top-quality UK-based brand of NR
If you are looking to buy an NR supplement made in the UK, VitalityPRO may be an ideal choice. Moreover, the brand ships to the USA, Australia, and other EU countries.
VitalityPRO is a 98.5% pure NR supplement containing no artificial colors, preservatives, or allergens. The brand utilizes stable nicotinamide riboside chloride as the only ingredient in the supplement.
Although the brand doesn't mention the source of its raw materials, the manufacturing of this NAD+ supplement takes place in cGMP-certified and ISO 9001 facilities.
VitalityPRO NR supplement contains no fillers, and the capsules are made from vegetable cellulose. The brand recommends people with no known health concerns take 1–2 capsules daily to receive 300–600 mg NR.
One bottle of VitalityPRO NR supplement costs $64.00 ($1.42 per serving). The price per serving depends on the daily consumption.
What users like about VitalityPRO
The customer reviews for VitalityPRO, though limited in number, highlight several positive aspects:
- Sleep and energy improvements
- Clear packaging
- Good value for the price
What users don’t like about VitalityPRO
The customers have highlighted key areas for improvement that VitalityPRO should address:
- Poor delivery experience
- Lack of temperature control during delivery
- General issues with delivery
Company review
Ideal for health-conscious individuals seeking supplements that may be both effective and environmentally responsible, VitalityPRO's biodegradable packaging underscores their dedication to sustainability.
Based in the UK, VitalityPRO is a forward-thinking company specializing in high-quality supplements. Their commitment to rigorous testing and adherence to UK ISO 9001 quality standards ensures reliability and production safety in every product.
Our verdict about VitalityPRO
VitalityPRO emerges as a compelling choice for those seeking a high-quality NR supplement crafted in the UK. Despite delayed international shipments and packaging issues, the customers like the brand’s offer of good value for the price and some potential health improvements.
Comparing the top NR supplements of 2025
| Brand | Price* | Price per serving | Servings per bottle | Serving size | NR dose per serving | Additional ingredients | NR form |
| partiQlar | $54.99 | $0.92 | 60 | 1 capsule | 500 mg | - | NR |
| ProHealth | $64.95 | $2.16 | 30 | 2 capsules | 500 mg | TMG (betaine) | NR chloride (NIAGEN®) |
| GenuinePurity™ | $69.95 | $2.33 | 30 | 2 capsules | 300 mg | - | Liposomal NR |
| Elysium | $60.00 | $2.00 | 30 | 2 capsules | 250 mg | Pterostilbene | Crystalline NR |
| Tru Nigen® | $119.95 | $1.33 | 90 | 1 capsule | 300 mg | - | NR chloride (NIAGEN®) |
| VitalityPRO | $64.00 | $1.42 | 45 | 2 capsules | 600 mg | - | NR chloride |
*prices vary depending on the product serving size and dosage selection, and daily consumption.
How did we evaluate the best NR supplements?
To select the best NR supplement in 2025, we considered the following quality criteria.
| Formulation | Third-party tested | Manufacturing | Price per serving |
| Increased NR bioavailability | Purity and quality | cGMP facilities | $0.92–2.00 |
- Formulation. When picking the best NR products, we considered what measures were taken to help enhance the bioavailability of NR supplements.
- Third-party testing. Although this is not mandatory for supplement brands, manufacturers aiming to ensure their product’s purity and quality should display third-party testing conducted by independent labs.
- Manufacturing. Another quality measure is the manufacturing of the supplements in advanced facilities that follow cGMP standards for developing contaminant-free products.
- Price per serving. NR products on our list are reasonably priced depending on the formulation and doses. The price per serving is the range of your spending on your daily NR consumption.
Your guide to nicotinamide riboside (NR) supplements in 2025
Here’s everything you need to know about NR supplements, their ingredients, and potential benefits.
NR: what it is & how it works
NR, or nicotinamide riboside, is a form of vitamin B3 that has gained popularity for its potential health benefits and proposed anti-aging effects. NR is suggested to convert into nicotinamide adenine dinucleotide (NAD+) in the body, which is a critical molecule involved in energy production, DNA repair, cellular health, and more.
Although research about NR is warranted, the available evidence suggests the effects of this agent in various health aspects, such as supporting metabolic and cellular function, liver health. NR is also currently being investigated for its potential to reduce blood pressure. Keep in mind that the long-term benefits of NR have yet to be established with clinical research.
In summary, NR shows promise as a molecule that may help support healthy aging. Despite the encouraging evidence, it is important to consult your healthcare provider before starting any NR supplement.
How to choose the right product for you?
To help ensure you are buying a quality NR supplement to meet your health needs, you should pay close attention to the following factors when analyzing the market:
- Purity. Make sure to check the purity indication of the nicotinamide riboside supplement made by the provider on the official website. NR supplements with low purity are more likely to contain compounds that may interact differently with the body and have different bioactive profiles.
- Ingredients. Check additional ingredients and whether they also align with your current wellness goals. Also, read the supplement label to ensure it’s free from GMOs and, in case of intolerances, soy, gluten, nuts, or other allergens.
- Customer reviews. Read customer feedback on review platforms or the product page to learn about the company’s approach to delivery, customer support, product packaging, and overall brand reputation.
- Dosage per serving. Supplements used in higher doses may pose a risk of side effects. Therefore, select products incorporating ingredients in doses that have been evaluated in clinical studies and reported to be generally well tolerated.
What are the benefits of NR supplements?
NR or nicotinamide riboside supplements are attracting interest for their association with enhancing NAD+ (nicotinamide adenine dinucleotide) levels.
Although the evidence comes mainly from animal or limited studies with humans, the research evolving around NR benefits suggests the following health effects:
- Healthy metabolism. Limited evidence suggests that NR supplementation may be associated with SIRT1 gene activation. As a result, this process may trigger higher energy production and contribute to metabolic health. It may also mimic certain aspects of caloric restriction. However, evidence of the possible metabolic health effects of NR supplementation in humans is still limited.
- Liver support. Although the evidence comes from mice studies and has not yet been applied to humans, NR supplementation was observed to promote liver regeneration and improve liver health in non-alcoholic fatty liver disease.
- Reduced blood pressure. A small clinical study, expected to be finalized by the end of the year, hypothesizes that supplementation with nicotinamide riboside may help reduce blood pressure and aortic stiffness. However, study results are still pending.
- Healthy aging. Currently, NR supplementation is promoted to promote longevity by supporting metabolism and reducing chronic inflammation — the latter being a hallmark of accelerated aging. However, more research is needed.
NR vs. NMN supplements: what is the difference?
First and foremost, it is crucial to note that NMN is no longer available as a dietary supplement due to the latest FDA investigation into whether it can be labeled as a drug. Yet, for people looking for ways to enhance NAD+ levels, NR is a good alternative to NMN.
Can NR supplements cause any side effects?
Although there are limited studies on NR supplementation in humans, so far, NR supplementation has not demonstrated significant side effects. Commonly, the providers recommend taking up to 500 mg NR daily, which is an amount used in studies without exposing individuals to adverse effects.
People also report feeling:
- Nausea
- Bloating
- Fatugue
- Headaches
- Itching
Pregnant or breastfeeding women, people under 18 years of age, and individuals with known health conditions should consult with their healthcare provider before supplementing with this NAD+ precursor.
NR dosage: how much you should take?
There are no official recommendations on the appropriate daily dose of NR. The recommended daily dosage of nicotinamide riboside (NR) by supplement manufacturers typically ranges from 100 to 300 mg. Most research suggests that doses up to 300 mg are safe and well-tolerated for general health support. Factors like age, health conditions, and specific wellness goals can influence the ideal dosage.
However, it's crucial to consult with a healthcare professional before starting NR supplementation to ensure the dosage is safe and suitable for your individual health needs.
NR food sources: getting it naturally
NR can be found in trace amounts in certain foods, particularly milk and dairy products, as well as yeast-containing foods like beer and bread. Fish, poultry, and pork also contain small quantities of NR. However, the levels present in these foods are relatively low. For instance, a single serving of milk provides only a few micrograms of NR, far below the amounts used in most supplement studies.
Because of this, relying solely on dietary sources may not provide enough NR for you to get any health benefits. In this case, supplementation might be a more efficient way to increase NR levels.
Other NAD+ boosters: exploring your options
Besides NR, other products like nicotinamide mononucleotide (NMN) may also increase NAD+ levels.
NMN is often praised for its direct conversion to NAD+ in cells, potentially leading to quicker results. However, limited research exists on how NMN and NR are converted to NAD+, so it is difficult to draw conclusions. Also, NMN typically costs more compared to NR. NMN is currently banned from being sold as a dietary supplement. NR, on the other hand, holds a Generally Recognized as Safe approval from the FDA.
While both NMN and NR may offer similar benefits for energy production, cellular repair, and healthy aging, NR's more established safety profile and availability on the market make it a popular choice for many looking to support NAD+ levels.
Best NR supplement worth your attention — bottom line
Despite the limited amount of scientific evidence, NR supplements are gaining popularity as NMN alternatives. Nicotinamide riboside demonstrates promising longevity properties by elevating NAD+ levels and supporting healthy aging.
NR is being widely marketed as a longevity supplement, making it challenging to find a quality product suitable for individual health needs. If you want to find the best NR supplement on the market, you should pay close attention to the supplement quality aspects.
FAQ
What are the benefits of the best nicotinamide riboside supplement?
NR supplements may bring numerous benefits to support healthy aging, including metabolic and liver health support and lower blood pressure. Note that these benefits have been observed in limited clinical trials and are emerging primarily from animal studies.
Can NMN and NR supplements be taken together?
No scientific findings or official guidelines suggest consuming NR and NMN together. Some people may be thinking of supplementing with both precursors to supposedly increase NAD+ levels more effectively. However, the key to healthy supplementation is moderation.
What is the daily recommended dosage for an NR supplement?
Some brands claim 500 mg NR daily as a general recommendation. The doses used in research studies vary from 250–1000 mg daily. To determine the safe doses for your individual health needs, you should talk to your doctor.
Can I experience any side effects from taking the best NR supplements?
Although NR supplements are generally known to be safe for consumption, side effects are possible. Commonly, in case of overconsumption or individual intolerances, people may experience tingling in their legs and toes, nausea, headaches, diarrhea, and itching.
5 resources
- Cell Reports. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
- Nature communications. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.
- The American Journal of Clinical Nutrition. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects.
- Scientific Reports. Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration.
- Aging and Mechanisms of Disease. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study.
Article history
Your email will not be published. All fields are required.